Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-α plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected pa...

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Veröffentlicht in:	The Lancet (British edition) 2001-01, Vol.357 (9252), p.280-281
Hauptverfasser:	Lafeuillade, Alain, Hittinger, Gilles, Chadapaud, Stephane
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antiretroviral drugs Antiretroviral Therapy, Highly Active Antiviral Agents - adverse effects Biological and medical sciences Computed tomography Deoxyribonucleic acid DNA Drug therapy Drug Therapy, Combination Drug toxicity and drugs side effects treatment Hepatitis Hepatitis C Hepatitis C - complications Hepatitis C - drug therapy Highly active antiretroviral therapy HIV HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Humans Infections Interferon Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Liver Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Mitochondria Mitochondrial DNA Mitochondrial Myopathies - chemically induced Nucleoside analogs Nucleosides Pancreatitis Patients Pharmacology. Drug treatments Ribavirin Ribavirin - adverse effects Toxicity Viruses
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Beschreibung
Zusammenfassung:	In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-α plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(00)03618-7