0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness
Abstract Introduction Caffeine is a stimulant often taken to reduce sleepiness and improve cognitive performance. The effect of caffeine on glucose metabolism during sleep deprivation is less well understood. This double-blind laboratory study examined the impact of caffeine on glucose metabolism, s...
Gespeichert in:
| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A84-A85 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | A85 |
|---|---|
| container_issue | suppl_1 |
| container_start_page | A84 |
| container_title | Sleep (New York, N.Y.) |
| container_volume | 41 |
| creator | Grant, C L Coates, A M Dorrian, J Paech, G M Pajcin, M Della Vedova, C Johnson, K Kamimori, G H Fidock, J Aidman, E Banks, S |
| description | Abstract
Introduction
Caffeine is a stimulant often taken to reduce sleepiness and improve cognitive performance. The effect of caffeine on glucose metabolism during sleep deprivation is less well understood. This double-blind laboratory study examined the impact of caffeine on glucose metabolism, self-reported hunger and mood state during 50h of wakefulness.
Methods
Participants were assigned to caffeine (n=9, 6M, age 21.3 ± 2.1y; BMI 21.9 ± 1.6kg/m2) or placebo conditions (n=8, 4M, age 23.0 ± 2.8y; BMI 21.8 ± 1.6kg/m2). Following a baseline sleep opportunity from 22:00h-08:00h, participants commenced 50h of extended wake. Caffeine (200mg) or placebo gum was administered at 01:00h, 03:00h, 05:00h and 07:00h during each night of extended wake. Continual glucose monitoring was used to capture interstitial glucose 2h post-breakfast, from which area under the curve (AUC) was calculated. Hunger and mood state were assessed at 10:00h, 16:30h, 22:30h and 04:30h.
Results
A significant rise in glucose AUC, in response to breakfast, was seen following the second night of extended wakefulness (p=0.003, ɳ2partial=0.32, large effect). Caffeine did not alter the glucose response, with no difference shown between conditions (p=0.680, ɳ2partial=0.01, small effect). Participants reported significant (p |
| doi_str_mv | 10.1093/sleep/zsy061.215 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2068452701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/sleep/zsy061.215</oup_id><sourcerecordid>2068452701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1475-a5ff72f4e3e3db10a9c0bed9fc98534d56d68b2ac526bfce09fbc295909a7c133</originalsourceid><addsrcrecordid>eNqFkDFPwzAQRi0EEqWwM1pihLS2Eyf1WJXSIrXq0CLGyHHOJSW1g51IlF-PIexMd6d73530ELqlZESJiMe-BmjGX_5EUjpilJ-hAeWcRCJsz9GA0JRGE0r4Jbry_kDCnIh4gBxhNMW7N8BzrUG1eKPxTIa2MoA3Bi_qTlkPeA2tLGxd-eMD3kKtIweNdS2UeNmZPTg8NSVeW1vibStbwI-dq8wezz9bMGWgXuU76K424P01utCy9nDzV4fo5Wm-my2j1WbxPJuuIkWTjEeSa50xnUAMcVlQIoUiBZRCKzHhcVLytEwnBZOKs7TQCojQhWKCCyJkpmgcD9Fdf7dx9qMD3-YH2zkTXuaMpJOEs4zQQJGeUs5670DnjauO0p1ySvIfs_mv2bw3mwezIXLfR2zX_E9_A3EufJA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068452701</pqid></control><display><type>article</type><title>0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Grant, C L ; Coates, A M ; Dorrian, J ; Paech, G M ; Pajcin, M ; Della Vedova, C ; Johnson, K ; Kamimori, G H ; Fidock, J ; Aidman, E ; Banks, S</creator><creatorcontrib>Grant, C L ; Coates, A M ; Dorrian, J ; Paech, G M ; Pajcin, M ; Della Vedova, C ; Johnson, K ; Kamimori, G H ; Fidock, J ; Aidman, E ; Banks, S</creatorcontrib><description>Abstract
Introduction
Caffeine is a stimulant often taken to reduce sleepiness and improve cognitive performance. The effect of caffeine on glucose metabolism during sleep deprivation is less well understood. This double-blind laboratory study examined the impact of caffeine on glucose metabolism, self-reported hunger and mood state during 50h of wakefulness.
Methods
Participants were assigned to caffeine (n=9, 6M, age 21.3 ± 2.1y; BMI 21.9 ± 1.6kg/m2) or placebo conditions (n=8, 4M, age 23.0 ± 2.8y; BMI 21.8 ± 1.6kg/m2). Following a baseline sleep opportunity from 22:00h-08:00h, participants commenced 50h of extended wake. Caffeine (200mg) or placebo gum was administered at 01:00h, 03:00h, 05:00h and 07:00h during each night of extended wake. Continual glucose monitoring was used to capture interstitial glucose 2h post-breakfast, from which area under the curve (AUC) was calculated. Hunger and mood state were assessed at 10:00h, 16:30h, 22:30h and 04:30h.
Results
A significant rise in glucose AUC, in response to breakfast, was seen following the second night of extended wakefulness (p=0.003, ɳ2partial=0.32, large effect). Caffeine did not alter the glucose response, with no difference shown between conditions (p=0.680, ɳ2partial=0.01, small effect). Participants reported significant (p<0.020) increases, with large effect sizes, for tiredness (ɳ2partial=0.68), mental exhaustion (ɳ2partial=0.61), irritability (ɳ2partial=0.35) and stress (ɳ2partial=0.48) on the second night of extended wakefulness compared to the first night. On the first, but not the second night (p<0.044), caffeine mitigated the rise in impairment, with medium-large effect sizes for the condition*night interaction for tiredness (ɳ2partial=0.40), mental exhaustion (ɳ2partial=0.14) and irritability (ɳ2partial= 0.23). Self-reported hunger was not affected by extended wake or caffeine.
Conclusion
Caffeine improved performance and reduced self-reported tiredness, mental exhaustion, and irritability under conditions of extended wake. However, the effectiveness appeared to be limited after 45 hours. Caffeine did not alter glucose metabolism over and above the effect of extended wakefulness.
Support (If Any)
This work was funded by Australian Defence Acquisition Project Land-121 and supported by the Defence Science and Technology (DST) Group. The US Army Medical Research and Material Command supported this work.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.215</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Caffeine ; Glucose ; Metabolism</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A84-A85</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Grant, C L</creatorcontrib><creatorcontrib>Coates, A M</creatorcontrib><creatorcontrib>Dorrian, J</creatorcontrib><creatorcontrib>Paech, G M</creatorcontrib><creatorcontrib>Pajcin, M</creatorcontrib><creatorcontrib>Della Vedova, C</creatorcontrib><creatorcontrib>Johnson, K</creatorcontrib><creatorcontrib>Kamimori, G H</creatorcontrib><creatorcontrib>Fidock, J</creatorcontrib><creatorcontrib>Aidman, E</creatorcontrib><creatorcontrib>Banks, S</creatorcontrib><title>0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
Caffeine is a stimulant often taken to reduce sleepiness and improve cognitive performance. The effect of caffeine on glucose metabolism during sleep deprivation is less well understood. This double-blind laboratory study examined the impact of caffeine on glucose metabolism, self-reported hunger and mood state during 50h of wakefulness.
Methods
Participants were assigned to caffeine (n=9, 6M, age 21.3 ± 2.1y; BMI 21.9 ± 1.6kg/m2) or placebo conditions (n=8, 4M, age 23.0 ± 2.8y; BMI 21.8 ± 1.6kg/m2). Following a baseline sleep opportunity from 22:00h-08:00h, participants commenced 50h of extended wake. Caffeine (200mg) or placebo gum was administered at 01:00h, 03:00h, 05:00h and 07:00h during each night of extended wake. Continual glucose monitoring was used to capture interstitial glucose 2h post-breakfast, from which area under the curve (AUC) was calculated. Hunger and mood state were assessed at 10:00h, 16:30h, 22:30h and 04:30h.
Results
A significant rise in glucose AUC, in response to breakfast, was seen following the second night of extended wakefulness (p=0.003, ɳ2partial=0.32, large effect). Caffeine did not alter the glucose response, with no difference shown between conditions (p=0.680, ɳ2partial=0.01, small effect). Participants reported significant (p<0.020) increases, with large effect sizes, for tiredness (ɳ2partial=0.68), mental exhaustion (ɳ2partial=0.61), irritability (ɳ2partial=0.35) and stress (ɳ2partial=0.48) on the second night of extended wakefulness compared to the first night. On the first, but not the second night (p<0.044), caffeine mitigated the rise in impairment, with medium-large effect sizes for the condition*night interaction for tiredness (ɳ2partial=0.40), mental exhaustion (ɳ2partial=0.14) and irritability (ɳ2partial= 0.23). Self-reported hunger was not affected by extended wake or caffeine.
Conclusion
Caffeine improved performance and reduced self-reported tiredness, mental exhaustion, and irritability under conditions of extended wake. However, the effectiveness appeared to be limited after 45 hours. Caffeine did not alter glucose metabolism over and above the effect of extended wakefulness.
Support (If Any)
This work was funded by Australian Defence Acquisition Project Land-121 and supported by the Defence Science and Technology (DST) Group. The US Army Medical Research and Material Command supported this work.</description><subject>Caffeine</subject><subject>Glucose</subject><subject>Metabolism</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkDFPwzAQRi0EEqWwM1pihLS2Eyf1WJXSIrXq0CLGyHHOJSW1g51IlF-PIexMd6d73530ELqlZESJiMe-BmjGX_5EUjpilJ-hAeWcRCJsz9GA0JRGE0r4Jbry_kDCnIh4gBxhNMW7N8BzrUG1eKPxTIa2MoA3Bi_qTlkPeA2tLGxd-eMD3kKtIweNdS2UeNmZPTg8NSVeW1vibStbwI-dq8wezz9bMGWgXuU76K424P01utCy9nDzV4fo5Wm-my2j1WbxPJuuIkWTjEeSa50xnUAMcVlQIoUiBZRCKzHhcVLytEwnBZOKs7TQCojQhWKCCyJkpmgcD9Fdf7dx9qMD3-YH2zkTXuaMpJOEs4zQQJGeUs5670DnjauO0p1ySvIfs_mv2bw3mwezIXLfR2zX_E9_A3EufJA</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Grant, C L</creator><creator>Coates, A M</creator><creator>Dorrian, J</creator><creator>Paech, G M</creator><creator>Pajcin, M</creator><creator>Della Vedova, C</creator><creator>Johnson, K</creator><creator>Kamimori, G H</creator><creator>Fidock, J</creator><creator>Aidman, E</creator><creator>Banks, S</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness</title><author>Grant, C L ; Coates, A M ; Dorrian, J ; Paech, G M ; Pajcin, M ; Della Vedova, C ; Johnson, K ; Kamimori, G H ; Fidock, J ; Aidman, E ; Banks, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1475-a5ff72f4e3e3db10a9c0bed9fc98534d56d68b2ac526bfce09fbc295909a7c133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Caffeine</topic><topic>Glucose</topic><topic>Metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grant, C L</creatorcontrib><creatorcontrib>Coates, A M</creatorcontrib><creatorcontrib>Dorrian, J</creatorcontrib><creatorcontrib>Paech, G M</creatorcontrib><creatorcontrib>Pajcin, M</creatorcontrib><creatorcontrib>Della Vedova, C</creatorcontrib><creatorcontrib>Johnson, K</creatorcontrib><creatorcontrib>Kamimori, G H</creatorcontrib><creatorcontrib>Fidock, J</creatorcontrib><creatorcontrib>Aidman, E</creatorcontrib><creatorcontrib>Banks, S</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grant, C L</au><au>Coates, A M</au><au>Dorrian, J</au><au>Paech, G M</au><au>Pajcin, M</au><au>Della Vedova, C</au><au>Johnson, K</au><au>Kamimori, G H</au><au>Fidock, J</au><au>Aidman, E</au><au>Banks, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A84</spage><epage>A85</epage><pages>A84-A85</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
Caffeine is a stimulant often taken to reduce sleepiness and improve cognitive performance. The effect of caffeine on glucose metabolism during sleep deprivation is less well understood. This double-blind laboratory study examined the impact of caffeine on glucose metabolism, self-reported hunger and mood state during 50h of wakefulness.
Methods
Participants were assigned to caffeine (n=9, 6M, age 21.3 ± 2.1y; BMI 21.9 ± 1.6kg/m2) or placebo conditions (n=8, 4M, age 23.0 ± 2.8y; BMI 21.8 ± 1.6kg/m2). Following a baseline sleep opportunity from 22:00h-08:00h, participants commenced 50h of extended wake. Caffeine (200mg) or placebo gum was administered at 01:00h, 03:00h, 05:00h and 07:00h during each night of extended wake. Continual glucose monitoring was used to capture interstitial glucose 2h post-breakfast, from which area under the curve (AUC) was calculated. Hunger and mood state were assessed at 10:00h, 16:30h, 22:30h and 04:30h.
Results
A significant rise in glucose AUC, in response to breakfast, was seen following the second night of extended wakefulness (p=0.003, ɳ2partial=0.32, large effect). Caffeine did not alter the glucose response, with no difference shown between conditions (p=0.680, ɳ2partial=0.01, small effect). Participants reported significant (p<0.020) increases, with large effect sizes, for tiredness (ɳ2partial=0.68), mental exhaustion (ɳ2partial=0.61), irritability (ɳ2partial=0.35) and stress (ɳ2partial=0.48) on the second night of extended wakefulness compared to the first night. On the first, but not the second night (p<0.044), caffeine mitigated the rise in impairment, with medium-large effect sizes for the condition*night interaction for tiredness (ɳ2partial=0.40), mental exhaustion (ɳ2partial=0.14) and irritability (ɳ2partial= 0.23). Self-reported hunger was not affected by extended wake or caffeine.
Conclusion
Caffeine improved performance and reduced self-reported tiredness, mental exhaustion, and irritability under conditions of extended wake. However, the effectiveness appeared to be limited after 45 hours. Caffeine did not alter glucose metabolism over and above the effect of extended wakefulness.
Support (If Any)
This work was funded by Australian Defence Acquisition Project Land-121 and supported by the Defence Science and Technology (DST) Group. The US Army Medical Research and Material Command supported this work.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.215</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A84-A85 |
| issn | 0161-8105 1550-9109 |
| language | eng |
| recordid | cdi_proquest_journals_2068452701 |
| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Caffeine Glucose Metabolism |
| title | 0216 The Effect Of Caffeine On Glucose Metabolism, Self-reported Hunger And Mood State During Extended Wakefulness |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A20%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=0216%20The%20Effect%20Of%20Caffeine%20On%20Glucose%20Metabolism,%20Self-reported%20Hunger%20And%20Mood%20State%20During%20Extended%20Wakefulness&rft.jtitle=Sleep%20(New%20York,%20N.Y.)&rft.au=Grant,%20C%20L&rft.date=2018-04-27&rft.volume=41&rft.issue=suppl_1&rft.spage=A84&rft.epage=A85&rft.pages=A84-A85&rft.issn=0161-8105&rft.eissn=1550-9109&rft_id=info:doi/10.1093/sleep/zsy061.215&rft_dat=%3Cproquest_cross%3E2068452701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2068452701&rft_id=info:pmid/&rft_oup_id=10.1093/sleep/zsy061.215&rfr_iscdi=true |