Herpes simplex virus 1 transmission through corneal transplantation

Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetratin...

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Veröffentlicht in:	The Lancet (British edition) 2001-02, Vol.357 (9254), p.442-442
Hauptverfasser:	Remeijer, Lies, Maertzdorf, Jeroen, Doornenbal, Peter, Verjans, Georges MGM, Osterhaus, Albert DME
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult Antibodies, Viral - blood Biological and medical sciences Blindness Congenital diseases Cornea Corneal transplantation Deoxyribonucleic acid DNA DNA Fingerprinting Eyes & eyesight Glaucoma Glaucoma - congenital Glaucoma - surgery Herpes simplex Herpes viruses Herpesvirus 1, Human - genetics Herpesvirus 1, Human - immunology Human viral diseases Humans Infections Infectious diseases Keratitis, Herpetic - immunology Keratitis, Herpetic - transmission Keratitis, Herpetic - virology Keratoplasty, Penetrating Male Medical sciences Mutation Patients Polymerase Chain Reaction Reoperation Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Tissue Donors Transplantation Transplants & implants Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Virus Activation Viruses
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Beschreibung
Zusammenfassung:	Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor derived HSV-1 in the transplanted cornea.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(00)04011-3