Antiproliferative Activities of Some Biologically Important Scaffolds

Among other factors, inherent and acquired resistance to treatment and the dose-limiting toxicity caused by the narrow therapeutic window of many cancer drugs are major obstacles in effective cancer therapy. Since clinically useful drugs have problems with toxicity, drug resistance and bioavailability, there is an ongoing effort to find new compounds that may be safer or more effective. According to docking studies, the A-ring containing 3.4.5-trimethoxyphenyl plays an important role in the inhibition of tubulin polymerization. Flow cytometric analysis of cultured cells treated with 21 also demonstrated that the compound caused cell cycle arrest at the G2/M phase in HL-60 and HeLa cells. [...]21 caused an apoptotic cell death through the activation of caspase-3. According to the studies for mechanism of action such as flow cytometry, fluorescence staining and DNA fragmentation in MCF7 cell lines, it was determined that the compounds stopped the cell cycle in G1 phase and the cells were shown to induce apoptosis (Reddy et al., 2015).