Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy

Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy

Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, w...

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Veröffentlicht in:MRS communications 2018-06, Vol.8 (2), p.398-403
Hauptverfasser: Tsolekile, Ncediwe, Ncapayi, Vuyelwa, Parani, Sundararajan, Sakho, El Hadji Mamour, Matoetoe, Mangaka C., Songca, Sandile P., Oluwafemi, Oluwatobi S.
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Cancer therapies
Conjugation
Efficiency
Fluorescence
Fourier transforms
Nanocrystals
Photodynamic therapy
Porphyrins
Quantum dots
Research Letters
Singlet oxygen
Sodium
Spectrum analysis
Synthesis
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Zusammenfassung:Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.
ISSN:2159-6859
2159-6867
DOI:10.1557/mrc.2018.60