LIPIDOMIC ANALYSIS REVEALS THE SIGNIFICANT INCREASE OF DIACYLGLYCEROPHOSPHOCHOLINES IN UMBILICAL CORD BLOOD FROM PREGNANT WOMEN WITH GESTATIONAL HYPERCHOLESTEROLEMIA

Background and objectives: Gestational hypercholesterolemia has been recognized as risk factors of some pregnancy complications. We supposed that maternal hypercholesterolemia modified the lipid profile of fetus. Methods: Thirty hypercholesterolemic pregnant women and matched controls were recruited and cord blood was sampled. Lipidomic analysis was used to evaluate the lipid profile change between the two groups. Results: The results showed that content of diacylglycerophosphocholines (PC) were significantly affected. PC (16:0/20:4) and PC (18:0/20:4) were selected as the most important lipid spices in cord plasma which positive related to total cholesterol (TC) and high density lipoprotein cholesterol (HDL) levels in cord blood. The contents of these two PCs were significantly high in hyperchplesterolemic group than that in control group. Conclusions: These results suggested that gestational hypercholesterolemia might program the phospholipide metabolism in offspring.