EFFECTS OF BIOMARKER INFLAMMATORY AND CARDIOMETABOLIC ON QUALITY OF LIFE OF BRAZILIAN OLDER ADULTS: HEALTH, WELL-BEING AND AGING STUDY (SABE STUDY)

Background and objectives: Scientific evidence shows relationship of chronic inflammation, elevated cardiometabolic biomarker levels and quality of life (QoL). This study verified associate of elevated inflammatory and cardiometabolic biomarker levels, in older adults with impaired quality of life, in different domains. Methods: Cross-sectional population-based study (SABE Study), including older adults (≥ 60 years-old). The inflammatory and cardiometabolic biomarkers used were uric acid, fibrinogen, C-reactive protein serum levels e glycated hemoglobin, fasting blood glucose, triglycerides and cholesterol, respectively, determined using sensitive regular immunoassays (ELISA). QoL was assessed using the SF12 questionnaire. Socio-demographic information and health conditions used as control variables were: sex, age and educational level; number of non-communicable diseases, self-reported conditions (chronic pains, hypertension, diabetes and cardiovascular disease), functional capacity, body mass index and waist circumference, respectively, determined using specific questionnaire. Multiple logistic regression was used to analyze this association. Results: From the 1.344 older adults, 1255 were eligible to be part of this study. There was no association of uric acid, fibrinogen, fasting blood glucose, triglycerides and cholesterol with QoL. Older adults with one or more chronic diseases (OR =1.75, p = 0,000), hypertension (OR =2.35; p = 0,000), BMI higher than 30kg/m2 (OR =2.25, p = 0,000), high levels of CRP (OR =2.85, p = 0,000) and glycated hemoglobin (OR =1.31, p = 0,000), were associated with low values in the physical domain of SF12. Conclusions: The joint associations elevated inflammatory and cardiometabolic biomarker levels have a significant and negative effect on physical domain of quality of life in older adults, demonstrating the importance of control of these biomarkers for better physical well-being.