Synthesis of 8a-Chlorotetrahydropyrrolo[1,2-H]pyrazine-1,6,7-(2H)-triones from 3-Methylidenepiperazin-2-ones and Oxalyl Chloride

Synthesis of 8a-Chlorotetrahydropyrrolo[1,2-H]pyrazine-1,6,7-(2H)-triones from 3-Methylidenepiperazin-2-ones and Oxalyl Chloride

( Z )-1-Aryl-3-(2-aryl-2-oxoethylidene)piperazin-2-ones react with oxalyl chloride at cooling with the formation of ( Z )-2-aryl-8-[hydroxy(aryl)methylidene]-8а-chlorotetrahydropyrrolо[1,2- a ]pyrazine-1,6,7(2 H )-triones. At heating HCl is eliminated from them to produce 8-aroyl-3,4-dihydropyrrolо[...

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Veröffentlicht in:Russian journal of organic chemistry 2018-05, Vol.54 (5), p.807-809
Hauptverfasser: Chervyakov, А. V., Dmitriev, М. V., Maslivets, А. N.
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Chemistry
Chemistry and Materials Science
Organic Chemistry
Short Communications
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Zusammenfassung:( Z )-1-Aryl-3-(2-aryl-2-oxoethylidene)piperazin-2-ones react with oxalyl chloride at cooling with the formation of ( Z )-2-aryl-8-[hydroxy(aryl)methylidene]-8а-chlorotetrahydropyrrolо[1,2- a ]pyrazine-1,6,7(2 H )-triones. At heating HCl is eliminated from them to produce 8-aroyl-3,4-dihydropyrrolо[1,2- а ]pyrazine- 1,6,7(2 H )-triones.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428018050263