Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women

Objective: Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation on CV disease are not clarified. We evaluated the impact of vitD normalization on lipoprotein functions, such as the HDL cholesterol efflux capacity (CEC), which is inversel...

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Veröffentlicht in:Vascular pharmacology 2018-04, Vol.103-105, p.69-69
Hauptverfasser: Greco, D., Kocyigit, D., Adorni, M.P., Marchi, C., Ronda, N., Bernini, F., Murat Gurses, K., Canpinar, H., Guc, D., Hanife Oguz, S., Gurlek, A., Tokgozoglu, L., Zimetti, F.
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Sprache:eng
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Zusammenfassung:Objective: Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation on CV disease are not clarified. We evaluated the impact of vitD normalization on lipoprotein functions, such as the HDL cholesterol efflux capacity (CEC), which is inversely correlated to CV risk, the pro-atherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis in women. Methods: Healthy premenopausal women with vitD deficiency (n = 31) underwent vitD supplementation. HDL CEC and serum CLC was measured by a radioisotopic and fluorimetric assay respectively. Serum adipokines were measured by ELISA. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (Alx), measured with standard techniques. Results: VitD replacement restored normal levels of serum 25-hydroxyvitamin D (250HD). Total CEC significantly improved (+19.5%; p
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2017.12.060