Rare Copy Number Variants: A Point of Rarity in Genetic Risk for Bipolar Disorder and Schizophrenia

Rare Copy Number Variants: A Point of Rarity in Genetic Risk for Bipolar Disorder and Schizophrenia

Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has recei...

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Veröffentlicht in:JAMA psychiatry (Chicago, Ill.) Ill.), 2010-04, Vol.67 (4), p.318
Hauptverfasser: Grozeva, Detelina, Kirov, George, Ivanov, Dobril, Jones, Ian R, Jones, Lisa, Green, Elaine K, St Clair, David M, Young, Allan H, Ferrier, Nicol, Farmer, Anne E, McGuffin, Peter, Holmans, Peter A, Owen, Michael J, O'Donovan, Michael C, Craddock, Nick
Format: Artikel
Sprache:eng
Schlagworte:
Autism
Bipolar disorder
Genomics
Medical diagnosis
Psychiatry
Risk factors
Schizophrenia
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Zusammenfassung:Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date. To determine whether large (>100 000 base pairs) and rare (found in
ISSN:2168-622X
2168-6238