Isolation of a Human Intestinal Bacterium Capable of Daidzein and Genistein Conversion

A rod-shaped gram-positive anaerobic bacterium, strain HE8, was isolated from human feces. The isolate was able to convert the isoflavones daidzein and genistein to equol and 5-hydroxy-equol, respectively. Based on phenotypic and phylogenetic analyses, strain HE8 is described as a new species, Slack...

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Veröffentlicht in:	Applied and Environmental Microbiology 2009-03, Vol.75 (6), p.1740-1744
Hauptverfasser:	Matthies, Anastasia, Blaut, Michael, Braune, Annett
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria - classification Actinobacteria - genetics Actinobacteria - isolation & purification Actinobacteria - metabolism Aerobiosis Biological and medical sciences Chemical compounds DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Ribosomal - chemistry DNA, Ribosomal - genetics Equol Feces Feces - microbiology Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology Genes, rRNA Genetics Genistein - metabolism Genotype & phenotype Gram-positive bacteria Humans Isoflavones - metabolism Microbial Ecology Microbiology Molecular Sequence Data Phylogeny RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics Sequence Analysis, DNA Sequence Homology, Nucleic Acid
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Zusammenfassung:	A rod-shaped gram-positive anaerobic bacterium, strain HE8, was isolated from human feces. The isolate was able to convert the isoflavones daidzein and genistein to equol and 5-hydroxy-equol, respectively. Based on phenotypic and phylogenetic analyses, strain HE8 is described as a new species, Slackia isoflavoniconvertens.
ISSN:	0099-2240 1098-5336
DOI:	10.1128/AEM.01795-08