Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus

New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host f...

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Veröffentlicht in:	Applied and Environmental Microbiology 2010-04, Vol.76 (8), p.2681-2683
Hauptverfasser:	Stevens, D. Cole, Henry, Michael R, Murphy, Kimberly A, Boddy, Christopher N
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Biofilms Biological and medical sciences Biosynthetic Pathways - genetics Biotechnology Deoxyribonucleic acid DNA Fundamental and applied biological sciences. Psychology Gene expression Gene Order Genes Genomics Microbiology Multigene Family Myxococcus xanthus Myxococcus xanthus - genetics Oxytetracycline - biosynthesis Recombinant Proteins - biosynthesis Recombinant Proteins - genetics
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Zusammenfassung:	New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
ISSN:	0099-2240 1098-5336 1098-6596
DOI:	10.1128/AEM.02841-09