Glycerol Utilization Gene Cluster in Streptomyces clavuligerus

The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1-deleted mutant. Amplification of glpK1D1 results in tra...

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Veröffentlicht in:	Applied and Environmental Microbiology 2009-05, Vol.75 (9), p.2991-2995
Hauptverfasser:	Baños, Sonia, Pérez-Redondo, Rosario, Koekman, Bert, Liras, Paloma
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Clavulanic acid Clavulanic Acid - biosynthesis DNA, Bacterial - chemistry DNA, Bacterial - genetics Fundamental and applied biological sciences. Psychology Gene Deletion Gene Dosage Gene expression Gene Expression Profiling Gene Order Genes, Bacterial Genetics and Molecular Biology Glucose Glucose - metabolism Glycerol - metabolism Gram-positive bacteria Metabolic Networks and Pathways - genetics Microbiology Molecular Sequence Data Multigene Family Mutation Sequence Analysis, DNA Streptomyces - genetics Streptomyces - growth & development Streptomyces clavuligerus
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Zusammenfassung:	The Streptomyces clavuligerus ATCC 27064 glycerol cluster gylR-glpF1K1D1 is induced by glycerol but is not affected by glucose. S. clavuligerus growth and clavulanic acid production are stimulated by glycerol, but this does not occur in a glpK1-deleted mutant. Amplification of glpK1D1 results in transformants yielding larger amounts of clavulanic acid in the wild-type strain and in overproducer S. clavuligerus Gap15-7-30 or S. clavuligerus ΔrelA strains.
ISSN:	0099-2240 1098-5336 1098-6596
DOI:	10.1128/AEM.00181-09