Effect of hexane extract of Syzygium aromaticum on haematological profile of rats

To analyse the effect of hexane extract of Syzygium aromaticum on haematological profile of rats. Previously, hexane extract of S. aromaticum buds at a high dose of 5000 mg kg-1 was given to one rat and the corresponding control received saline water as vehicle. It was repeated and no mortality was observed. Based on the result, 2000 mg kg-1 was selected for the main study. The rats were prorated into two groups (control and treated). Each group consisted of six rats. After administration of hexane extract, blood was collected from three rats per group at an interval of 1 hr (retero-orbital plexus); 24 hrs and 14 day (cardiac puncture) in ethylenediaminetetraacetic acid coated vials and signs of toxicity and mortality were observed in animals. Haematological parameters were estimated from collected blood samples using automatic haematological analyser (Model MeletSchloesing MS4). The hexane extract of S. aromaticum at a dose of 2000 mg kg-1 b. wt. to male rats did not produce any change in haematological profile for 1 hr exposure. The changes were observed in monocytes and white blood cells after 24 hrs. Significant (P