Design and wet-laboratory implementation of reliable end-to-end molecular communication

This paper describes a novel design and wet laboratory implementation of reliable end-to-end molecular communication. In the reliable end-to-end molecular communication described in this paper, source and destination bio-nanomachines exchange molecular packets through intermediate bio-nanomachines that are capable of packet replication. A source bio-nanomachine forms a molecular packet and transmits the molecular packet into the environment. An intermediate bio-nanomachine detects a molecular packet and produces its copies through packet replication. A destination bio-nanomachine, upon reception of a molecular packet, produces an acknowledgment molecular packet and transmits back to the source bio-nanomachine. This paper describes how the reliable end-to-end molecular communication can be biochemically implemented with RNA (ribonucleic acid) molecules and artificial cell systems. It also describes a simulation-based performance evaluation study showing the impact of model parameters on propagation delay in the reliable end-to-end molecular communication.