Phyllaciduloids A–D: Four new cleistanthane diterpenoids from Phyllanthus acidus (L.) Skeels

Four new cleistanthane diterpenoids, phyllaciduloids A–D (1–4), were isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were elucidated on the basis of extensive spectroscopic analysis. Phyllaciduloids B–D (2–4) present in their structures with ether bond between C-7 and C-16, which were rarely reported. All the isolates were evaluated for their cytotoxic activities against five human cancer cell lines. [Display omitted]