Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues
New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C -nucleosides, were synthesized. Novel O -glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compo...
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| Veröffentlicht in: | Russian journal of general chemistry 2018-04, Vol.88 (4), p.815-824 |
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| container_issue | 4 |
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| container_title | Russian journal of general chemistry |
| container_volume | 88 |
| creator | Soliman, H. A. Kotb, E. R. El-Bayaa, M. N. Kutkat, O. M. Abdel-Magied, F. M. E. |
| description | New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic
C
-nucleosides, were synthesized. Novel
O
-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds
5a
,
9a
, and
14
demonstrated high inhibition activity. |
| doi_str_mv | 10.1134/S1070363218040291 |
| format | Article |
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C
-nucleosides, were synthesized. Novel
O
-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds
5a
,
9a
, and
14
demonstrated high inhibition activity.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363218040291</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Antiretroviral drugs ; Antiviral agents ; Aromatic compounds ; Avian flu ; Avian influenza ; Avian influenza viruses ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Derivatives ; Health aspects ; Hydrazones ; Nucleosides ; Pharmaceutical industry ; Pyridine ; Pyridines ; Substitutes ; Viruses</subject><ispartof>Russian journal of general chemistry, 2018-04, Vol.88 (4), p.815-824</ispartof><rights>Pleiades Publishing, Ltd. 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-d327b6653f06aa5ba2f8703821e6f4fe3c4017df8cd5acc66999225a4c78c93e3</citedby><cites>FETCH-LOGICAL-c383t-d327b6653f06aa5ba2f8703821e6f4fe3c4017df8cd5acc66999225a4c78c93e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363218040291$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363218040291$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Soliman, H. A.</creatorcontrib><creatorcontrib>Kotb, E. R.</creatorcontrib><creatorcontrib>El-Bayaa, M. N.</creatorcontrib><creatorcontrib>Kutkat, O. M.</creatorcontrib><creatorcontrib>Abdel-Magied, F. M. E.</creatorcontrib><title>Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic
C
-nucleosides, were synthesized. Novel
O
-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds
5a
,
9a
, and
14
demonstrated high inhibition activity.</description><subject>Antiretroviral drugs</subject><subject>Antiviral agents</subject><subject>Aromatic compounds</subject><subject>Avian flu</subject><subject>Avian influenza</subject><subject>Avian influenza viruses</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Derivatives</subject><subject>Health aspects</subject><subject>Hydrazones</subject><subject>Nucleosides</subject><subject>Pharmaceutical industry</subject><subject>Pyridine</subject><subject>Pyridines</subject><subject>Substitutes</subject><subject>Viruses</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LJDEQQBtZQVf9Ad4avLiHdvPRnU4fm2HVBVFh9NxkKskYyXTGJC3Gu_97446LLCp1SEi9V1WhiuIQoxOMaf1zjlGLKKMEc1Qj0uGtYhczxCtKG_Qt33O6es3vFN9DuEcII8TIbvEyT2O8U8GEUoyy7MdoqvPmEpc9RPNoYiqdLufTIkQTp6hkeZ28kWZU5ZlN4IKRamMeXz0JacSzs8n-cE9ppeJdsut_dA8JrIFyVl1OYNVfMXcT1i0nFfaLbS1sUAdv515xe_rrZnZeXVyd_Z71FxVQTmMlKWkXjDVUIyZEsxBE8_xrTrBiutaKQo1wKzUH2QgAxrquI6QRNbQcOqroXnG0qbv27iH3jcO9m3yeIgwENYQzTjv8Ti2FVYMZtYtewMoEGPqWsIbnYJk6-YTKIdXKgBuVNvn9PwFvBPAuBK_0sPZmJXwaMBpelzh8WGJ2yMYJmR2Xyr8P_LX0B1_bngA</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Soliman, H. A.</creator><creator>Kotb, E. R.</creator><creator>El-Bayaa, M. N.</creator><creator>Kutkat, O. M.</creator><creator>Abdel-Magied, F. M. E.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180401</creationdate><title>Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues</title><author>Soliman, H. A. ; Kotb, E. R. ; El-Bayaa, M. N. ; Kutkat, O. M. ; Abdel-Magied, F. M. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-d327b6653f06aa5ba2f8703821e6f4fe3c4017df8cd5acc66999225a4c78c93e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antiretroviral drugs</topic><topic>Antiviral agents</topic><topic>Aromatic compounds</topic><topic>Avian flu</topic><topic>Avian influenza</topic><topic>Avian influenza viruses</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Derivatives</topic><topic>Health aspects</topic><topic>Hydrazones</topic><topic>Nucleosides</topic><topic>Pharmaceutical industry</topic><topic>Pyridine</topic><topic>Pyridines</topic><topic>Substitutes</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soliman, H. A.</creatorcontrib><creatorcontrib>Kotb, E. R.</creatorcontrib><creatorcontrib>El-Bayaa, M. N.</creatorcontrib><creatorcontrib>Kutkat, O. M.</creatorcontrib><creatorcontrib>Abdel-Magied, F. M. E.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soliman, H. A.</au><au>Kotb, E. R.</au><au>El-Bayaa, M. N.</au><au>Kutkat, O. M.</au><au>Abdel-Magied, F. M. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2018-04-01</date><risdate>2018</risdate><volume>88</volume><issue>4</issue><spage>815</spage><epage>824</epage><pages>815-824</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic
C
-nucleosides, were synthesized. Novel
O
-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds
5a
,
9a
, and
14
demonstrated high inhibition activity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363218040291</doi><tpages>10</tpages></addata></record> |
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| ispartof | Russian journal of general chemistry, 2018-04, Vol.88 (4), p.815-824 |
| issn | 1070-3632 1608-3350 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Antiretroviral drugs Antiviral agents Aromatic compounds Avian flu Avian influenza Avian influenza viruses Chemistry Chemistry and Materials Science Chemistry/Food Science Derivatives Health aspects Hydrazones Nucleosides Pharmaceutical industry Pyridine Pyridines Substitutes Viruses |
| title | Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues |
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