Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C -nucleosides, were synthesized. Novel O -glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compo...

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Veröffentlicht in:Russian journal of general chemistry 2018-04, Vol.88 (4), p.815-824
Hauptverfasser: Soliman, H. A., Kotb, E. R., El-Bayaa, M. N., Kutkat, O. M., Abdel-Magied, F. M. E.
Format: Artikel
Sprache:eng
Schlagworte:
Antiretroviral drugs
Antiviral agents
Aromatic compounds
Avian flu
Avian influenza
Avian influenza viruses
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Health aspects
Hydrazones
Nucleosides
Pharmaceutical industry
Pyridine
Pyridines
Substitutes
Viruses
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Zusammenfassung:New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C -nucleosides, were synthesized. Novel O -glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a , 9a , and 14 demonstrated high inhibition activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218040291