Oleic Acid and Angiotensin II Induce a Synergistic Mitogenic Response in Vascular Smooth Muscle Cells

Oleic acid and angiotensin II (Ang II) are elevated and may interact to accelerate vascular disease in obese hypertensive patients. We studied the effects of oleic acid and Ang II on growth responses of rat aortic smooth muscle cells (VSMCs). Oleic acid (50 [micro sign]mol/L) raised thymidine incorp...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-04, Vol.31 (4), p.978-985
Hauptverfasser:	Lu, Gang, Meier, Kathryn E, Jaffa, Ayad A, Rosenzweig, Steven A, Egan, Brent M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Angiotensin Receptor Antagonists Animals Aorta - cytology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - drug effects Cardiology. Vascular system Cell Count - drug effects Cell Division - drug effects Cells, Cultured - drug effects Drug Synergism Experimental diseases JNK Mitogen-Activated Protein Kinases Medical sciences Mitogen-Activated Protein Kinases Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Oleic Acid - pharmacology Oligonucleotides, Antisense - pharmacology p38 Mitogen-Activated Protein Kinases Pharmaceutic Aids - pharmacology Rats Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Vasoconstrictor Agents - pharmacology
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Beschreibung
Zusammenfassung:	Oleic acid and angiotensin II (Ang II) are elevated and may interact to accelerate vascular disease in obese hypertensive patients. We studied the effects of oleic acid and Ang II on growth responses of rat aortic smooth muscle cells (VSMCs). Oleic acid (50 [micro sign]mol/L) raised thymidine incorporation by 50% at 24 hours and cell number by 55% at 6 days (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.hyp.31.4.978