Castleman's Disease Mimicking a Parotid Gland Tumor

Castleman disease (CD) is a rare benign lymphoproliferative disorder of unknown etiology, typically presenting as a solitary mediastinal mass. The head and neck region is the most common site; however, the salivary glands are rarely affected. We present a rare case of a 59-year- old male patient with mixed type CD localized in the parotid gland. The patient underwent a left superficial parotidectomy with a clinical prediagnosis of mucoepidermoid carcinoma. H&E stained sections showed mostly preserved lymph node architecture. Some lymphoid follicles had atrophic germinal centers and mantle zones was expanded. Also there were sclerotic blood vessels radially penetrated the germinal centers and the overall appearance of the follicle was resembling a lollipop. The diagnosis was CD, mixed type. For the accurate diagnosis of this entity, histopathological examination should be performed and physicians should kept in mind this clinical entity so patients can receive adequate and early treatment.