Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications. Cucurbit[7]uril inhibited the seizure-inducing neurotoxicity of a chemical on both zebrafish and mice, suggesting its significant clinical potential in toxicity-modulation.