Internal Na(plus) and Mg(2plus) blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes: Inward rectification of a delayed rectifier

Internal Na(plus) and Mg(2plus) blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes: Inward rectification of a delayed rectifier

Delayed rectifier potassium channels were expressed in the membrane of Xenopus oocytes by injection of rat brain DRK1 (Kv2.1) cRNA, and currents were measured in cell-attached and inside-out patch configurations. The findings suggest that inward going rectification resulting from voltage-dependent b...

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Veröffentlicht in:The Journal of general physiology 1994-02, Vol.103 (2), p.203
Hauptverfasser: Lopatin, A N, Nichols, C G
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Cellular biology
Membranes
Potassium
Rodents
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Zusammenfassung:Delayed rectifier potassium channels were expressed in the membrane of Xenopus oocytes by injection of rat brain DRK1 (Kv2.1) cRNA, and currents were measured in cell-attached and inside-out patch configurations. The findings suggest that inward going rectification resulting from voltage-dependent block by internal cations can be observed with normally outwardly rectifying DRK1 channels.
ISSN:0022-1295
1540-7748