Pt(II) and Ni(II) complexes of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives: Synthesis, characterization, physical parameters and biological activity

In this study, four novel Pt(II) and Ni(II) complexes of the octahydropyrrolo[3,4-c]pyrrole, consisting of pyrrolidine fused to pyrrolidine-2,5-dione, N-benzoylthiourea derivatives were synthesized and their structural characterization was performed by NMR, FT-IR, MS and HRMS techniques and single crystal X-ray diffraction studies. The octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea compound 3c crystallizes triclinic, space group P-1. Pt(II) and Ni(II) ions created cis-complexes Pt(II) 4c and Ni(II) 5a forming distorted square-planar structures in orthorhombic space groups Pnma and Pbca, respectively. Acid dissociation constants of the ligands and stability constants of their Pt(II) and Ni(II) complexes were determined by potentiometric titration method in 25% (v/v) acetonitrile-water hydroorganic solvent at 25±0.1°C, at an ionic background of 0.1mol/L of NaCl using the HYPERQUAD computer program. Antibacterial activity of the ligands and their complexes was investigated against S. aureus, B. subtilis, A. hydrophila, E. coli and A. baumannii standard bacterial strains, and their antimycobacterial activity was investigated against the M. tuberculosis H37Rv strain. [Display omitted] •Synthesis of four novel Pt(II) and Ni(II) complexes of the octahydropyrrolo[3,4-c]pyrrole, consisting of pyrrolidine fused to pyrrolidine-2,5-dione, N-benzoylthiourea derivatives.•Acid dissociation constants study of the ligands.•Stability constants study of the Pt(II) and Ni(II) complexes.•Anti(myco)bacterial activity studies for the ligands and their Pt(II) and Ni(II) complexes.•X-ray study for the ligand, Pt(II) and Ni(II) complexes. In this study, four novel Pt(II) and Ni(II) complexes of octahydropyrrolo[3,4-c]pyrrole, consisting of pyrrolidine fused to pyrrolidine-2,5-dione, N-benzoylthiourea derivatives were synthesized and their structural characterization was performed by NMR, FT-IR, MS, HRMS and elemental analysis techniques and single crystal X-ray diffraction studies. The octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea compound 3c crystallizes triclinic, with space group P-1. Pt(II) and Ni(II) ions created cis-complexes Pt(II) 4c and Ni(II) 5a forming distorted square-planar structures in orthorhombic space groups Pnma and Pbca, respectively. Furthermore, the ligands behave as bidentate and bind to the metal atom via the S and O atoms. Acid dissociation constants of the ligands were determined by potentiometric titration method in 25% (v/v) acetonitrile-water hydro