Sonogashira cross-coupling reaction catalyzed by N-heterocyclic carbene-Pd(II)-PPh3 complexes under copper free and aerobic conditions

[Display omitted] NHC-Pd-PPh3 complexes with the bulky N-heterocyclic carbene (NHC) ligands were synthesized and proceeded to Sonogashira-Hagihara coupling reaction between aryl bromides and phenylacatylene by low catalyst loading in DMF under copper free conditions. •Pd-NHC catalysed the Sonogashira coupling reaction of aryl bromides were examined. NHC-Pd-PPh3 complexes with the bulky benzyladamantyl substited N-heterocyclic carbene (NHC) were synthesized and characterised by NMR, HRMS and micro analyse. These complexes were proceeded to Sonogashira-Hagihara coupling reaction between aryl bromides and phenylacatylene in DMF. All palladium compounds are stable and have high catalytic activity on Sonogashira-Hagihara reaction by low catalyst loading.