Effects of magnesium chloride on in vitro cholinesterase and ATP ase poisoning by organophosphate (chlorpyrifos)
The present study investigated possible benefits of magnesium ion (as MgCl 2 ) in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes. Blood samples collected from volunteered healthy adult by venepuncture into anticoagulant test tubes containing EDTA we...
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Veröffentlicht in: | Pharmacology research & perspectives 2018-06, Vol.6 (3) |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | The present study investigated possible benefits of magnesium ion (as MgCl
2
) in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes. Blood samples collected from volunteered healthy adult by venepuncture into anticoagulant test tubes containing
EDTA
were separated into plasma and red blood cell and divided into three groups namely: normal, pesticide only (0.25‐2.0 mmol/L chlorpyrifos) and pesticide (0.25‐2.0 mmol/L chlorpyrifos) + 0.1 mol/L MgCl
2
. Acetylcholinesterase, Na
+
/K
+
ATP
ase and Ca
2+
ATP
ase activities were evaluated. Results showed that Chlorpyrifos significantly (
P
|
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ISSN: | 2052-1707 2052-1707 |
DOI: | 10.1002/prp2.401 |