Estimation Tnf-Ágene Polymorphisms in Patients with Behcet's Disease in Babylon Province - Iraq

The serum level of tumor necrosis factor (TNF) is elevated in patients with BD. The aim of this meta-analysis was to assess the association between TNF gene polymorphisms and BD. Materials and Methods: A hospital-based case-control study design was carried out on (34) patients with Behcet disease and control group seen at Rheumatology outpatient clinic in Merjan Teaching Hospital in Babylon Iraq, all patients and control were from the same ethnic group ( Arabic). Abbreviations: BD Behcet's disease, TNF-_ Tumor necrosis factor-alpha, HLA Human leukocyte antigen, PCR-RFLP Polymerase chain reaction-restriction fragment length polymorphism, PCR-SSCP single strand complement polymorphism techniques. Genetic factor suggested that polymorphisms of several genes such as human leukocyte antigens- B51 (HLAB51), intercellular adhesion molecule-1 (ICAM-1), and tumor necrosis factor- alpha (TNF-alpha) are associated with increased susceptibility to BD. HLA-B51 is the most strongly associated gene with BD in different ethnic populations (7). Since the clear pathogenesis of BD remains to be elucidated, it is highly suggestive that multiple host genetic factors are involved in the development of BD (19).