Studies on the Synthesis of some new 1, 2, 4-Triazoles Derivatives and Evaluation for their Anti-Tubercular activity profiles

Incorporation of oxygen, nitrogen, sulphur, or an atom of a related element into an organic ring structure in place of a carbon atom gives rise to a heterocyclic compound. Since the heterocyclic atom must form more than one bond in order to be incorporated into a ring structure, halogens do not form heterocyclic compounds although they may be substituents on a heterocyclic ring structure. [...]there exists, urgent need for the discovery of newer molecules, which may have potential to curb the above mentioned infectious diseases. 3,5-disubstituted 1,2,4-triazole and its derivatives have been reported to posses wide spectrum of activities ranging from anti-bacterials8, anti-inflammatory9, anti-convulsant10, antineoplastic11, antimalarial12, anti-viral13, anti-cancer14, anti-TB15 and anti-proliferative16. Purity of starting materials used for reaction was confirmed by checking their melting point or boiling point and by thin layer chromatography. b) Purity of compounds was checked on "Silica Gel G" coated on laboratory micro slides prepared by dipping method or precoated plates, eluent was the mixture of different polar and non-polar solvents in varying proportions and detection was done either by observing in UV (ultra-violet) light or exposure to iodine vapours as required. [...]in the present investigation all the synthesised 1,2,4-triazole derivatives (6a-6e).