Impact of interferon‐free regimens on the glomerular filtration rate during treatment of chronic hepatitis C in a real‐life cohort

Summary Little data are available on renal toxicity exerted by direct‐acting antivirals (DAAs) in real life. The aim of this study was to assess the impact of direct‐acting antivirals against hepatitis C virus infection currently used in Spain and Portugal on the estimated glomerular filtration rate...

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Veröffentlicht in:	Journal of viral hepatitis 2018-06, Vol.25 (6), p.699-706
Hauptverfasser:	Álvarez‐Ossorio, M. J., Sarmento e Castro, R., Granados, R., Macías, J., Morano‐Amado, L. E., Ríos, M. J., Merino, D., Álvarez, E. N., Collado, A., Pérez‐Pérez, M., Téllez, F., Martín, J. M., Méndez, J., Pineda, J. A., Neukam, K., Alados‐Arboledas, Juan Carlos, Albendín, Helena, Alemán, María Remedios, Alonso, María del Mar, Asensi, Victor, Blanco, María José, Cabo, Rebeca, Camacho, Ángela, Casas, Mario Frías, Castro, Ángeles, Cervantes, Manuel, Cucurull, Josep, Cuéllar, Sandra, Cuenca, Francisca, Delgado, Marcial, Domínguez, Lara, Dueñas, Carlos, Fernández, Elisa, Galera, Carlos, Gálvez, María Carmen, García, Dácil, Martínez, Paloma Geijo, Gómez, Ana, Gómez, Juan Luis, Gutiérrez, Félix, Hernández, José, Hernández, Jehovana, Llenas‐García, Jara, Márquez, Manuel, Martínez, Lorena, Martínez‐Álvarez, Rosa, Madrid, Onofre Martínez, Masiá, María del Mar, Merchante, Nicolás, Mínguez, Carlos, Montero‐Alonso, Marta, Omar, Mohamed, Ortega, Enrique, Padilla, Sergio, Robledano, Catarina, Pelazas, Ricardo, Pérez‐Camacho, Inés, Pernas, Berta, Portilla, Joaquín, Portu, José Joaquín, Raffo, Miguel, Real, Luis Miguel, Reina, Gabriel, Reus, Sergio, Rincón, Pilar, Rivero, Antonio, Rivero‐Juárez, Antonio, Romero‐Palacios, Alberto, Rubio, Purificación, Ryan‐Murua, Pablo, Saíz de la Hoya, Pablo, de los Santos‐Gil, Ignacio, Santos, Jesús, Saussol, Fernando, Serrano, Miriam, Toyas, Carla, Vera‐Méndez, Francisco Jesús, Hernández, Marina Villalobos, García, David Vinuesa
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - administration & dosage Anilides - adverse effects Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Carbamates - administration & dosage Carbamates - adverse effects direct antiviral agents Epidermal growth factor receptors Female Glomerular Filtration Rate HCV Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy HIV HIV Infections - complications HIV Infections - drug therapy Human immunodeficiency virus Humans Interferon Macrocyclic Compounds - administration & dosage Macrocyclic Compounds - adverse effects Male Middle Aged Patients Portugal Prospective Studies Proteinase inhibitors Renal function Retrospective Studies Ritonavir Spain Sulfonamides - administration & dosage Sulfonamides - adverse effects Tenofovir Toxicity Treatment Outcome Uracil - administration & dosage Uracil - adverse effects Uracil - analogs & derivatives
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Zusammenfassung:	Summary Little data are available on renal toxicity exerted by direct‐acting antivirals (DAAs) in real life. The aim of this study was to assess the impact of direct‐acting antivirals against hepatitis C virus infection currently used in Spain and Portugal on the estimated glomerular filtration rate (eGFR) in clinical practise. From an international, prospective multicohort study, patients treated with DAAs for at least 12 weeks and with eGFR ≥30 mL/min per 1.73 m2 at baseline were selected. eGFR was determined using the CKD‐EPI formula. A total of 1131 patients were included; 658 (58%) were HIV/HCV‐coinfected patients. Among the 901 patients treated for 12 weeks, median (interquartile range) eGFR was 100 (87‐107) at baseline vs 97 (85‐105) mL/min per 1.73 m2 at week 12 of follow‐up (FU12) post‐treatment (P 60 mL/min per 1.73 m2 at baseline, 22 (2%) had eGFR
ISSN:	1352-0504 1365-2893
DOI:	10.1111/jvh.12867