Directing group assisted ZnI2-catalyzed cyclopropanation of indoles via 2-furylcarbenoids

Directing group assisted ZnI2-catalyzed cyclopropanation of indoles via 2-furylcarbenoids

A directing group promoting the cyclopropanation of indoles with 2-furylcarbenoids has been developed. These carbenes are derived from enynones and cost-effective ZnI2 is employed as the catalyst for the efficient construction of various polycyclic compounds under mild reaction conditions.

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Veröffentlicht in:Organic chemistry frontiers an international journal of organic chemistry 2018-06, Vol.5 (11), p.1768-1771
Hauptverfasser: Chen, Wei, Dong-Sheng, Ji, Yong-Chun, Luo, Zhu-Yin, Wang, Peng-Fei, Xu
Format: Artikel
Sprache:eng
Schlagworte:
Carbenes
Indoles
Organic chemistry
Polycyclic compounds
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Zusammenfassung:A directing group promoting the cyclopropanation of indoles with 2-furylcarbenoids has been developed. These carbenes are derived from enynones and cost-effective ZnI2 is employed as the catalyst for the efficient construction of various polycyclic compounds under mild reaction conditions.
ISSN:2052-4110
2052-4110
DOI:10.1039/c8qo00232k