Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided st...

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Veröffentlicht in:	Angewandte Chemie 2018-06, Vol.130 (23), p.6979-6983
Hauptverfasser:	Xu, Feng, Kosjek, Birgit, Cabirol, Fabien L., Chen, Haibin, Desmond, Richard, Park, Jeonghan, Gohel, Anupam P., Collier, Steven J., Smith, Derek J., Liu, Zhuqing, Janey, Jacob M., Chung, John Y. L., Alvizo, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biokatalyse Chemistry Enzyme Gerichtete Evolution Ketoreduktasen pH effects Reduction Synthesis Totalsynthese
Online-Zugang:	Volltext
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