ETS rearrangements and prostate cancer initiation/Tomlins et al. reply

Most prostate cancer specimens with ERG genetic rearrangements do not show this rearrangement in the associated HGPIN. [...] the TMPRSS2:ERG translocation seems to be an early event in human prostate tumorigenesis, but one associated with progression from HGPIN to cancer. Brett S. Carver1,3, Jennifer Tran1, Zhenbang Chen1,5, Arkaitz Carracedo-Perez1, Andrea Alimonti1,5, Caterina Nardella1,5, Anuradha Gopalan2, Peter T. Scardino3, Carlos Cordon-Cardo4, William Gerald2 & Pier Paolo Pandolfi1,2,5 1Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. e-mail: ppandolf@bidmc.harvard.edu 2Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. 3Department of Surgery, Division of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. 4Department of Pathology, Columbia University, New York, New York 10032, USA. 5Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.