Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

To investigate the role of TNFR1 in beneficial and detrimental activities of tumor necrosis factor (TNF), TNFR1-deficient mice were generated by gene targeting. Mice homozygous for a disrupted Tnfr1 allele are resistant to the lethal effect of low doses of lipopolysaccharide after sensitization with...

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Veröffentlicht in:Nature (London) 1993-08, Vol.364 (6440), p.798-802
Hauptverfasser: Rothe, Joachim, Lesslauer, Werner, Lötscher, Hansruedi, Lang, Yolande, Koebel, Pascale, Köntgen, Frank, Althage, Alana, Zinkernagel, Rolf, Steinmetz, Michael, Bluethmann, Horst
Format: Artikel
Sprache:eng
Schlagworte:
Biology
Rodents
Tumors
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Zusammenfassung:To investigate the role of TNFR1 in beneficial and detrimental activities of tumor necrosis factor (TNF), TNFR1-deficient mice were generated by gene targeting. Mice homozygous for a disrupted Tnfr1 allele are resistant to the lethal effect of low doses of lipopolysaccharide after sensitization with D-galactosamine.
ISSN:0028-0836
1476-4687
DOI:10.1038/364798a0