OC-010 Phenotyping Trichuris colitis reveals innate and adaptive immunological commonalities to human Crohn's disease

OC-010 Phenotyping Trichuris colitis reveals innate and adaptive immunological commonalities to human Crohn's disease

IntroductionTrichuris muris, an intestinal dwelling nematode, induces chronic colitis in susceptible mouse strains. Pathology is characterised by patchy, full thickness colonic inflammation, similar to Crohn's disease (CD). Conversely, resistant mouse strains exhibit transient acute infection (...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gut 2010-04, Vol.59 (Suppl 1), p.A4-A5
Hauptverfasser: Levison, S E, McLaughlin, J T, Zeef, L, Pennock, J L
Format: Artikel
Sprache:eng
Schlagworte:
Body weight
Body weight loss
Colitis
Colon
Crohn's disease
Data processing
Diarrhea
Exploration
Gene expression
Genotypes
Helper cells
Hypertrophy
Immune response
Immunoglobulin G
Immunology
Infections
Inflammation
Inflammatory bowel disease
Interleukin 21
Interleukin 6
Intestine
Lymphocytes T
Mucosa
Ova
Phagocytosis
Phenotypes
Phenotyping
Statistical analysis
Transcription factors
Transforming growth factor-b
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:IntroductionTrichuris muris, an intestinal dwelling nematode, induces chronic colitis in susceptible mouse strains. Pathology is characterised by patchy, full thickness colonic inflammation, similar to Crohn's disease (CD). Conversely, resistant mouse strains exhibit transient acute infection (×1.2-fold upregulation cf. naïve, p
ISSN:0017-5749
1468-3288
DOI:10.1136/gut.2009.208934j