LOX-1, an Oxidized LDL Endothelial Receptor, Induces CD40/CD40L Signaling in Human Coronary Artery Endothelial Cells

BACKGROUND—Despite increasing appreciation that atherogenesis involves participation of inflammatory cells, information on mediators of communication between different constituents of atherosclerotic plaque remain incomplete. We examined the role of LOX-1, a receptor for oxidized (ox) LDL, in the ex...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-05, Vol.23 (5), p.816-821
Hauptverfasser:	Li, Dayuan, Liu, Ling, Chen, Hongjiang, Sawamura, Tatsuya, Mehta, Jawahar L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis - etiology CD40 Antigens - biosynthesis CD40 Antigens - genetics CD40 Antigens - physiology CD40 Ligand - biosynthesis CD40 Ligand - genetics CD40 Ligand - physiology Cells, Cultured - drug effects Cells, Cultured - physiology Coronary Vessels - cytology Coronary Vessels - physiology Endothelial Cells - drug effects Endothelial Cells - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Humans Lipoproteins, LDL - pharmacology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein Kinase C-alpha Protein Subunits Receptors, LDL - drug effects Receptors, LDL - physiology Signal Transduction - drug effects Signal Transduction - physiology Tumor Necrosis Factor-alpha - analysis Vasculitis - chemically induced Vasculitis - metabolism
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Zusammenfassung:	BACKGROUND—Despite increasing appreciation that atherogenesis involves participation of inflammatory cells, information on mediators of communication between different constituents of atherosclerotic plaque remain incomplete. We examined the role of LOX-1, a receptor for oxidized (ox) LDL, in the expression of CD40/CD40L in cultured human coronary artery endothelial cells (HCAECs). METHODS AND RESULTS—We observed that ox-LDL increased the expression of CD40 and CD40L in a concentration (10 to 80 μg/mL)- and time (1 to 24 hours)- dependent manner. These effects of ox-LDL were mediated by activation of LOX-1, because pretreatment of HCAECs with a blocking antibody to LOX-1 (JTX92) prevented the expression of CD40 and CD40L in response to ox-LDL (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.ATV.0000066685.13434.FA