Combined Hepatoprotective Activity of Murraya koenigii and Phyllanthus niruri Extracts Against Paracetamol Induced Hepatotoxicity in Alcoholic Rats

The present study elucidated the hepatoprotective activity of combination of alcohol water extracts (AWEs) of Murraya koenigii (AWEMK) and Phyllanthus niruri (AWEPN) leaves against paracetamol induced hepatic damage in ethanol exposed rats. Phytochemical analysis of AWEs determined the presence of f...

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Veröffentlicht in:Proceedings of the National Academy of Sciences, India. Section B: Biological sciences India. Section B: Biological sciences, 2018-06, Vol.88 (2), p.655-665
Hauptverfasser: Shah, Pallavi, Singh, S. P., Gupta, Atul Kumar, Kumar, Anil
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Sprache:eng
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Zusammenfassung:The present study elucidated the hepatoprotective activity of combination of alcohol water extracts (AWEs) of Murraya koenigii (AWEMK) and Phyllanthus niruri (AWEPN) leaves against paracetamol induced hepatic damage in ethanol exposed rats. Phytochemical analysis of AWEs determined the presence of flavonoids and phenols, followed by high performance liquid chromatography determination of an important antioxidant tannic acid in AWEMK and a major bioactive lignan phyllanthin in AWEPN. Gas chromatography mass spectrometric analysis revealed the presence of carbazole alkaloids in AWEMK whereas AWEPN was found rich in sterols. Prolonged consumption of ethanol has been reported to enhance the hepatic damage caused by paracetamol overdose by induction of cytochrome P450 (CYP450) and depletion of reduced glutathione (GSH) in alcohol abusers. Oral administration of alcohol (5 ml/kg/day) for three days followed by paracetamol (500 mg/kg, b.i.d.) for another 3 days produced liver damage in rats as manifested by the significant ( P  
ISSN:0369-8211
2250-1746
DOI:10.1007/s40011-016-0800-5