Transition Metal‐Free sp3 C–H Functionalization of Arylacetic Acids for the Synthesis of 1,3,5‐Triazines

A one‐pot simple, efficient and practically viable protocol for the synthesis of substituted 1,3,5‐triazines has been reported from arylacetic acids and benzamidine hydrochloride. In addition, we demonstrated first transition metal‐free conversion of phenylacetic acid to benzaldehyde which on condensation with two equivalents of benzamidine hydrochloride offered 2,4,6‐trisubstituted 1,3,5‐triazines. This protocol is environmentally benign and economically viable which makes it feasible for gram scale synthesis. An efficient transition metal‐free protocol for the synthesis of 1,3,5‐trisubstituted triazines has been developed through C–H functionalization of arylacetic acids by using K2CO3 as a base, followed by condensation with substituted benzamidine hydrochloride.