Iridium(III)‐Catalyzed Directed ortho‐C(sp2)–H Amidation of Arenes with Sulfonamides

Iridium(III)‐Catalyzed Directed ortho‐C(sp2)–H Amidation of Arenes with Sulfonamides

An iridium(III)‐catalyzed ortho‐C(sp2)–H amidation of O‐methyl ketoximes with sulfonamides has been accomplished under mild conditions. This protocol can be successfully applied to a broad scope of oxime substrates and works well with a range of aryl‐ and alkylsulfonamides. A mild and efficient Cp*I...

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Veröffentlicht in:European journal of organic chemistry 2018-05, Vol.2018 (18), p.2071-2077
Hauptverfasser: Zhang, Wei, Yang, Darun, Wang, Wengui, Wang, Shoufeng, Zhao, Huaiqing
Format: Artikel
Sprache:eng
Schlagworte:
Amidation
Aromatic compounds
Cyclopentadienyl ligands
C–H functionalization
Iridium
Ketoximes
Substrates
Sulfonamides
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Beschreibung
Zusammenfassung:An iridium(III)‐catalyzed ortho‐C(sp2)–H amidation of O‐methyl ketoximes with sulfonamides has been accomplished under mild conditions. This protocol can be successfully applied to a broad scope of oxime substrates and works well with a range of aryl‐ and alkylsulfonamides. A mild and efficient Cp*IrIII‐catalyzed (Cp* = pentamethylcyclopentadienyl) ortho‐C(sp2)–H amidation of O‐methyl ketoximes with sulfonamides is developed and furnishes the corresponding products in good yields.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201800192