6-Shogaol and mycophenolic acid are seen to act synergistically in combination with platinum drug in killing ovarian cancer cells

An abstract of the study by Anwar et al applying combinations of platinum drugs such as cisplatin, oxaliplatin and carboplatin with natural compounds such as mycophenolic acid, honokiol, cholecalciferol and 6-shogaol to ovarian cancer cell lines towards synergistic outcomes, is presented. MTT reduction assay was used to determine the IC50 values. In combination studies, drugs were administered to the cell lines at constant ratios of their IC50 values using the sequences. Results were 6-Shogaol showed prominent synergism in combination with oxaliplatin and cisplatin when administered as a bolus (0/0 h) and when using 0/4 h sequence. Furthermore, 6-Shogaol showed significant synergism in combination with cisplatin and oxaliplatin against ovarian cancer tumour models when administered as a bolus.