Analysis of the combinatorial effect of cisplatin and VE-821 on a large panel of tumor cell lines

An abstract of the study conducted by Chakrabarti et al analyzing the combinatorial effect of cisplatin and VE-821 on a large panel of tumor cells is presented. The study found that applying the combination of cisplatin and VE-821 in a checkerboard pattern on a large number of different cell lines allowed us to correlate observed synergistic and non-synergistic effects with gene expression profiles of these cell lines and to validate the requirement of an ATM/p53 defective signaling. Moreover, the approach has allowed to determine which ratio of the compounds is most effective for which cell line. By these means, the study will contribute to understanding of combinatorial effects of genotoxic agents and ATR-inhibitors.