NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations

NAMPT inhibition is a novel synthetic lethal therapeutic approach exploiting nuclear–mitochondrial crosstalk in ERCC1-deficient populations

An abstract of a study by Touat et al identifying novel synthetic lethal therapeutic approach exploiting nuclear-mitochondrial crosstalk in ERCC1-deficient populations is presented. They found marked metabolic rewiring of ERCC1-deficient populations, including decreased NAMPT levels, decreased NAD+...

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Veröffentlicht in:European journal of cancer (1990) 2016-12, Vol.69, p.S56-S56
Hauptverfasser: Touat, M, Olaussen, K, Sourisseau, T, Friboulet, L, Dorvault, N, Enot, D, Bigot, L, Pontoizeau, C, Mardakheh, F, Thompson, A, Bouillaud, F, Ricchetti, M, Ottolenghi, C, Pierron, G, Sarasin, A, Lombès, A, Ashworth, A, Lord, C, Soria, J.C, Postel-Vinay, S
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities
Crosstalk
DNA repair
ERCC1 protein
Hematology, Oncology and Palliative Medicine
Lung cancer
Mitochondria
Mitochondrial DNA
NAD
Population
Populations
Rewiring
Targeted cancer therapy
Tricarboxylic acid cycle
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Zusammenfassung:An abstract of a study by Touat et al identifying novel synthetic lethal therapeutic approach exploiting nuclear-mitochondrial crosstalk in ERCC1-deficient populations is presented. They found marked metabolic rewiring of ERCC1-deficient populations, including decreased NAMPT levels, decreased NAD+ levels and abnormalities in the tricarboxylic acid cycle.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(16)32753-8