Revisiting the roles of TP53, IDH1/IDH2, BRAF, H3F3A, HIST1H3B as diagnostic markers and their clinical significance in glioma tumorigenesis

An abstract of a study by Sarma et al on revisiting the roles of TP53, IDH1/IDH2, BRAF, H3F3A, HIST1H3B as diagnostic markers and their clinical significance in glioma tumorigenesis is presented. Non duplicate 55 newly diagnosed glioma patients who underwent surgery were considered for the study. Results indicate that genetic alterations in TP53 was highly prevalent among different grades of tumour and most of the TP53 SNPs were found to be harmful in nature as revealed by Polyphen-2. The study suggests that despite being established as important diagnostic or prognostic marker in gliomagenesis, clinical significance of the studied biomarkers remains questionable in the present study population.