Transcription control by the ENL YEATS domain in acute leukemia

Transcription control by the ENL YEATS domain in acute leukemia

Recurrent chromosomal translocations involving the mixed lineage leukemia gene (MLL) give rise to highly aggressive acute leukemia associated with poor clinical outcomes. The preferential involvement of chromatin-associated factors in MLL rearrangements belies a dependency on transcriptional control...

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Veröffentlicht in:European journal of cancer (1990) 2016-12, Vol.69, p.S85-S86
Hauptverfasser: Erb, M, Winter, G, Dastjerdi, S, Scott, T, Sanjana, N, Shalem, O, Buckley, D, Zhang, F, Bradner, J
Format: Artikel
Sprache:eng
Schlagworte:
Chromatin
Chromosome translocations
CRISPR
Genes
Genetics
Genomes
Hematology, Oncology and Palliative Medicine
Leukemia
Target recognition
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Zusammenfassung:Recurrent chromosomal translocations involving the mixed lineage leukemia gene (MLL) give rise to highly aggressive acute leukemia associated with poor clinical outcomes. The preferential involvement of chromatin-associated factors in MLL rearrangements belies a dependency on transcriptional control. Here, an abstract of an article by Erb et al performing a genome-scale CRISPR-Cas9 knockout screen in MLL-AF4 leukemia to identify new targets for therapeutic development in MLL is presented.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(16)32850-7