Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa

Despite the benefits of rotavirus vaccination, concerns about intussusception are an important consideration. In this study, the risk of intussusception associated with rotavirus vaccination was assessed in African countries in which the vaccine had recently been rolled out.

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Veröffentlicht in:	The New England journal of medicine 2018-04, Vol.378 (16), p.1521-1528
Hauptverfasser:	Tate, Jacqueline E, Mwenda, Jason M, Armah, George, Jani, Bhavin, Omore, Richard, Ademe, Ayesheshem, Mujuru, Hilda, Mpabalwani, Evans, Ngwira, Bagrey, Cortese, Margaret M, Mihigo, Richard, Glover-Addy, Hope, Mbaga, Mwajabu, Osawa, Francis, Tadesse, Amezene, Mbuwayesango, Bothwell, Simwaka, Julia, Cunliffe, Nigel, Lopman, Benjamin A, Weldegebriel, Goitom, Ansong, Daniel, Msuya, David, Ogwel, Billy, Karengera, Thomas, Manangazira, Portia, Bvulani, Bruce, Yen, Catherine, Zawaira, Felicitas R, Narh, Clement T, Mboma, Lazaro, Saula, Peter, Teshager, Fasil, Getachew, Halle, Moeti, Rebecca M, Eweronu-Laryea, Christabel, Parashar, Umesh D
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa South of the Sahara - epidemiology Age Babies Clinical trials Disease control Disease prevention Drug dosages Fatalities Female Health surveillance Humans Immunization Immunization Schedule Incidence Infant Infants Intussusception Intussusception - epidemiology Intussusception - etiology Intussusception - mortality Intussusception - therapy Laboratories Low income groups Male Medical research Medicine Pediatrics Public health Risk Rotavirus Rotavirus Infections - prevention & control Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - adverse effects Surgery Time-to-Treatment Vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Viruses
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Beschreibung
Zusammenfassung:	Despite the benefits of rotavirus vaccination, concerns about intussusception are an important consideration. In this study, the risk of intussusception associated with rotavirus vaccination was assessed in African countries in which the vaccine had recently been rolled out.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1713909