0774 Trends In Rem Sleep Duration Among Obese Adolescents And The Association With Obstructive Sleep Apnea

Abstract Introduction Evidence suggests that rapid eye movement (REM) sleep may be protective against obesity due to association with hypocretin and leptin. The objective of this study is to explore the association between BMI Z-score, obstructive sleep apnea (OSA) severity, and REM sleep duration in overweight/obese adolescents. Methods This retrospective cohort study included overweight and obese adolescents (13–17 y/o) who underwent overnight polysomnography (PSG) at Children Hospital Los Angeles from 2010–2017. Individuals were excluded for history of chronic lung disease, craniofacial malformations, syndromic conditions, or primary neuromuscular disorders or if taking medications influencing sleep. Descriptive statistics included mean ± standard deviation and median. Results Ninety-two study participants (43% female) had a mean age of 14.9 ± 1.3 years. BMI Z-score was 2.27 ± 0.47 (median 2.28), with 71% having z-score ≥ 2. The percent of sleep time spent in REM (REM%) was 15.6 ± 6.80 (median 16.3). Overall obstructive apnea-hypopnea index was 17.1 ± 24.3 (median 4.55) events/hour. The distribution across categories of OSA severity was 27% (25) none (