0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort
Abstract Introduction Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyt...
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| creator | Tempaku, P F Hirotsu, C Mazzotti, D R Xavier, G Maurya, P K Rizzo, L B Brietzke, E Belangero, S I Poyares, D Bittencourt, L Tufik, S |
| description | Abstract
Introduction
Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep disorders in an adult general population sample.
Methods
As part of the EPISONO cohort (São Paulo, Brazil), 926 individuals answered questionnaires, underwent type 1 polysomnography (PSG) and clinical assessment, and had peripheral blood collected for DNA extraction. Obstructive sleep apnea (OSA) was defined according to apnea-hypopnea index (mild 5≤AHI |
| doi_str_mv | 10.1093/sleep/zsy061.034 |
| format | Article |
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Introduction
Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep disorders in an adult general population sample.
Methods
As part of the EPISONO cohort (São Paulo, Brazil), 926 individuals answered questionnaires, underwent type 1 polysomnography (PSG) and clinical assessment, and had peripheral blood collected for DNA extraction. Obstructive sleep apnea (OSA) was defined according to apnea-hypopnea index (mild 5≤AHI<15; moderate-severe AHI≥15/h) and insomnia was diagnosed according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). For the objective insomnia phenotype, we combined DSM-IV criterion with total sleep time from PSG with a cutoff of 360 min, allowing the classification of 6 groups: good sleeper TST≥360min, good sleeper TST<360min, insomnia symptoms TST≥360min, insomnia symptoms TST<360min, DSM-IV insomnia TST≥360min and DSM-IV insomnia TST>360min. Self-reported sleep duration was used to classify the individuals as short (<6 hours), average (6 to 8 hours) and long (>8 hours) sleepers. The LTL was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered LTL<10th percentile as short telomere and LTL≥10th percentile as no-short telomere.
Results
After adjustment for sex, age and body mass index, only DSM-IV insomnia (OR=2.654, 95%CI=1.025–6.873, p=0.044), DSM-IV insomnia TST<360min (OR=4.205, 95%CI=1.097–16.117, p=0.036) and long-sleepers (OR=2.177, 95%CI=1.189–3.987, p=0.012) were independently associated with short telomere. The final logistic regression model showed that age (OR=6.873, 95%CI=3.757–12.572, p<0.0001) and long-sleepers (OR=2.276, 95%CI=1.243–4.166, p=0.008) were the factors associated with short telomere.
Conclusion
Taken together, our findings support the existence of an association between objective and subjective sleep parameters and the molecular pathways of aging, especially those related to telomere length maintenance.
Support (If Any)
This work was supported by grants from AFIP, FAPESP and CNPq.]]></description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.034</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Insomnia ; Sleep</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A14-A14</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids></links><search><creatorcontrib>Tempaku, P F</creatorcontrib><creatorcontrib>Hirotsu, C</creatorcontrib><creatorcontrib>Mazzotti, D R</creatorcontrib><creatorcontrib>Xavier, G</creatorcontrib><creatorcontrib>Maurya, P K</creatorcontrib><creatorcontrib>Rizzo, L B</creatorcontrib><creatorcontrib>Brietzke, E</creatorcontrib><creatorcontrib>Belangero, S I</creatorcontrib><creatorcontrib>Poyares, D</creatorcontrib><creatorcontrib>Bittencourt, L</creatorcontrib><creatorcontrib>Tufik, S</creatorcontrib><title>0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort</title><title>Sleep (New York, N.Y.)</title><description><![CDATA[Abstract
Introduction
Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep disorders in an adult general population sample.
Methods
As part of the EPISONO cohort (São Paulo, Brazil), 926 individuals answered questionnaires, underwent type 1 polysomnography (PSG) and clinical assessment, and had peripheral blood collected for DNA extraction. Obstructive sleep apnea (OSA) was defined according to apnea-hypopnea index (mild 5≤AHI<15; moderate-severe AHI≥15/h) and insomnia was diagnosed according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). For the objective insomnia phenotype, we combined DSM-IV criterion with total sleep time from PSG with a cutoff of 360 min, allowing the classification of 6 groups: good sleeper TST≥360min, good sleeper TST<360min, insomnia symptoms TST≥360min, insomnia symptoms TST<360min, DSM-IV insomnia TST≥360min and DSM-IV insomnia TST>360min. Self-reported sleep duration was used to classify the individuals as short (<6 hours), average (6 to 8 hours) and long (>8 hours) sleepers. The LTL was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered LTL<10th percentile as short telomere and LTL≥10th percentile as no-short telomere.
Results
After adjustment for sex, age and body mass index, only DSM-IV insomnia (OR=2.654, 95%CI=1.025–6.873, p=0.044), DSM-IV insomnia TST<360min (OR=4.205, 95%CI=1.097–16.117, p=0.036) and long-sleepers (OR=2.177, 95%CI=1.189–3.987, p=0.012) were independently associated with short telomere. The final logistic regression model showed that age (OR=6.873, 95%CI=3.757–12.572, p<0.0001) and long-sleepers (OR=2.276, 95%CI=1.243–4.166, p=0.008) were the factors associated with short telomere.
Conclusion
Taken together, our findings support the existence of an association between objective and subjective sleep parameters and the molecular pathways of aging, especially those related to telomere length maintenance.
Support (If Any)
This work was supported by grants from AFIP, FAPESP and CNPq.]]></description><subject>Insomnia</subject><subject>Sleep</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkDFPwzAQhS0EEqWwM1piRGltx3aSsSoFKkUEqWWOXOfSpmrtYieg8i_4x7gtAxvLne7ue--kh9AtJQNKsnjoNwC74ZffE0kHJOZnqEeFIFEWrueoR6ikUUqJuERX3q9JmHkW99A3IbHAuTXL6OgAzmNlKjw13m5No_Bn067wbGVdi4vFGnTbfACeHVD80DnVNtZg5SAIqqAOxbSbPR55b3WjWqj-GsxhY7cQ4BzMMmwbg9sV4MnrdFa8FHhsD9Q1uqjVxsPNb--jt8fJfPwc5cXTdDzKI015wqNEA-eyokzzdBFzKqiUMiUiSStei5oyWZNEa7XgaZYAy2KhtGSSCVZDthBV3Ed3J9-ds-8d-LZc286Z8LJkJA5mCWFpoMiJ0s5676Aud67ZKrcvKSkPwZfH2MpT8GUIPkjuTxLb7f6nfwB9Q4cT</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Tempaku, P F</creator><creator>Hirotsu, C</creator><creator>Mazzotti, D R</creator><creator>Xavier, G</creator><creator>Maurya, P K</creator><creator>Rizzo, L B</creator><creator>Brietzke, E</creator><creator>Belangero, S I</creator><creator>Poyares, D</creator><creator>Bittencourt, L</creator><creator>Tufik, S</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort</title><author>Tempaku, P F ; Hirotsu, C ; Mazzotti, D R ; Xavier, G ; Maurya, P K ; Rizzo, L B ; Brietzke, E ; Belangero, S I ; Poyares, D ; Bittencourt, L ; Tufik, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1474-7ce446d12c48b3415166680578d4f5f126f07ccab4897e2935ac626252fe9b5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Insomnia</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tempaku, P F</creatorcontrib><creatorcontrib>Hirotsu, C</creatorcontrib><creatorcontrib>Mazzotti, D R</creatorcontrib><creatorcontrib>Xavier, G</creatorcontrib><creatorcontrib>Maurya, P K</creatorcontrib><creatorcontrib>Rizzo, L B</creatorcontrib><creatorcontrib>Brietzke, E</creatorcontrib><creatorcontrib>Belangero, S I</creatorcontrib><creatorcontrib>Poyares, D</creatorcontrib><creatorcontrib>Bittencourt, L</creatorcontrib><creatorcontrib>Tufik, S</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tempaku, P F</au><au>Hirotsu, C</au><au>Mazzotti, D R</au><au>Xavier, G</au><au>Maurya, P K</au><au>Rizzo, L B</au><au>Brietzke, E</au><au>Belangero, S I</au><au>Poyares, D</au><au>Bittencourt, L</au><au>Tufik, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A14</spage><epage>A14</epage><pages>A14-A14</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract><![CDATA[Abstract
Introduction
Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep disorders in an adult general population sample.
Methods
As part of the EPISONO cohort (São Paulo, Brazil), 926 individuals answered questionnaires, underwent type 1 polysomnography (PSG) and clinical assessment, and had peripheral blood collected for DNA extraction. Obstructive sleep apnea (OSA) was defined according to apnea-hypopnea index (mild 5≤AHI<15; moderate-severe AHI≥15/h) and insomnia was diagnosed according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). For the objective insomnia phenotype, we combined DSM-IV criterion with total sleep time from PSG with a cutoff of 360 min, allowing the classification of 6 groups: good sleeper TST≥360min, good sleeper TST<360min, insomnia symptoms TST≥360min, insomnia symptoms TST<360min, DSM-IV insomnia TST≥360min and DSM-IV insomnia TST>360min. Self-reported sleep duration was used to classify the individuals as short (<6 hours), average (6 to 8 hours) and long (>8 hours) sleepers. The LTL was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered LTL<10th percentile as short telomere and LTL≥10th percentile as no-short telomere.
Results
After adjustment for sex, age and body mass index, only DSM-IV insomnia (OR=2.654, 95%CI=1.025–6.873, p=0.044), DSM-IV insomnia TST<360min (OR=4.205, 95%CI=1.097–16.117, p=0.036) and long-sleepers (OR=2.177, 95%CI=1.189–3.987, p=0.012) were independently associated with short telomere. The final logistic regression model showed that age (OR=6.873, 95%CI=3.757–12.572, p<0.0001) and long-sleepers (OR=2.276, 95%CI=1.243–4.166, p=0.008) were the factors associated with short telomere.
Conclusion
Taken together, our findings support the existence of an association between objective and subjective sleep parameters and the molecular pathways of aging, especially those related to telomere length maintenance.
Support (If Any)
This work was supported by grants from AFIP, FAPESP and CNPq.]]></abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.034</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Insomnia Sleep |
| title | 0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort |
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