0035 Long-sleepers and Insomnia with Short Objective Sleep Duration are Independently Associated with Short Telomere Length in the EPISONO Cohort

Abstract Introduction Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep disorders in an adult general population sample. Methods As part of the EPISONO cohort (São Paulo, Brazil), 926 individuals answered questionnaires, underwent type 1 polysomnography (PSG) and clinical assessment, and had peripheral blood collected for DNA extraction. Obstructive sleep apnea (OSA) was defined according to apnea-hypopnea index (mild 5≤AHI