0532 Previous Palate or Hypopharyngeal Surgery Is Not Associated with Subsequent Efficacy of Cranial Nerve Stimulation for Obstructive Sleep Apnea

Abstract Introduction Upper Airway Stimulation has demonstrated efficacy in treating obstructive sleep apnea within a clinical trial. The Adherence and Outcome of Upper Airway Stimulation for OSA International Registry was developed to evaluate outcomes in a clinical practice setting, from 12 centers in the United States and Europe. The objective of this study was to examine whether having previous palate or hypopharyngeal surgery was associated with treatment efficacy. Methods The Registry cohort study includes individuals treated with this neurostimulation system. Efficacy was determined from the apnea-hypopnea index on sleep studies performed prior to implantation, following in-laboratory titration (on target settings), and final follow-up (≥12 months following implantation). The three efficacy criteria were the change in the apnea-hypopnea index from baseline and two definitions of therapy response; therapy response required ≥50% decrease in apnea-hypopnea index to