0614 Timing And Density Of Eeg Segments In The Hypersomnias: Implications For Circadian And Homeostatic Control Of Sleep

Abstract Introduction Narcolepsy with cataplexy (N-C) is characterized by destabilized sleep/wake and REM, but less is known about sleep structure in narcolepsy without cataplexy (NwC) and other hypersomnias. The goal of this study was to evaluate the microarchitecture of the NPSG in N-C and NwC cas...

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Veröffentlicht in:Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A228-A228
Hauptverfasser: Cairns, A, Bogan, R
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Sprache:eng
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Zusammenfassung:Abstract Introduction Narcolepsy with cataplexy (N-C) is characterized by destabilized sleep/wake and REM, but less is known about sleep structure in narcolepsy without cataplexy (NwC) and other hypersomnias. The goal of this study was to evaluate the microarchitecture of the NPSG in N-C and NwC cases compared to age-matched idiopathic hypersomnia (IH) and clinic-control (primary snoring) cases. Methods Fifty cases from each diagnostic group were gathered from SleepMed’s deidentified data repository (N=200). Children under 12 and those on CNS medications were excluded. EEG segment population and timing were analyzed using Morpheus, an automated processing software which decomposes EEG using adaptive segmentation with fuzzy clustering and feature extraction into a 4-frequency state model (high frequency [HF], low-frequency [LF], and mixed frequency with low or high energy [MF1 & MF2, respectively]). Results The amount of REM was remarkably similar for all groups (approximately 20%; p=.80) with all showing an increase in MF1 segments (REM surrogate) as the night progressed. However, the acrophase of MF1 segments occurred 45 minutes earlier for those with narcolepsy compared to controls (p
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsy061.613