0474 The Effects of Chronic Rhinosinusitis and Obstructive Sleep Apnea on Sleep Quality

Abstract Introduction Obstructive Sleep Apnea (OSA) and Chronic Rhinosinusitis (CRS) each negatively impact sleep quality, but their interaction has not been examined. In our World Trade Center (WTC) dust-exposed population with high prevalence of CRS symptoms and OSA we have shown CRS symptoms were an independent risk factor for OSA. This study examines their relative contributions to sleep quality. Methods CRS symptoms were obtained from 626 WTC (111M/515F, 33–87 yrs, BMI=29.96 ± 5.53 kg/m2) subjects. CRS+ was defined as ≥3 symptoms: facial pain, post nasal drip, nasal congestion, blocked nose, loss of smell, sneezing, sore throat/hoarseness. Difficulties initiating/maintaining sleep and overall quality of sleep were obtained via questionnaire. Functional Outcomes of Sleep Questionnaire (FOSQ) and Epworth Sleepiness Scale (ESS) were administered. Subjects underwent 2-night home sleep test (ARESTM) and AHI4 (apneas+hypopneas with 4% O2 desaturations) and RDI (apneas+ hypopneas with 4% desaturation or arousal surrogates) were calculated. OSA was defined as AHI4≥5/hr or RDI≥15/hr. Demographic and co-morbid medical condition data were obtained. Results 443/626 (70.7%) had OSA; Median AHI4=11/hr (IQR 6–20), Median RDI=26/hr (IQR 19–38); 43.6% mild OSA. 274 (43.8%) were CRS+ and 205 (32.9%) subjects had both CRS and OSA. CRS was associated with poor sleep quality (OR 2.39, 95%CI 1.65–3.46,p