Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo
Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting ma...
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| Veröffentlicht in: | Advanced healthcare materials 2018-05, Vol.7 (9), p.n/a |
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| creator | Zhou, Ping Zhao, Heng Wang, Quan Zhou, Zhiguo Wang, Jing Deng, Guang Wang, Xiyou Liu, Qian Yang, Hong Yang, Shiping |
| description | Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the αvβ3‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs.
A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αvβ3‐positive U87MG glioblastoma xenograft model. |
| doi_str_mv | 10.1002/adhm.201701201 |
| format | Article |
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A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αvβ3‐positive U87MG glioblastoma xenograft model.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201701201</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Fe@Fe3O4 nanoparticles ; Fever ; Glioblastoma ; Hyperthermia ; in vivo theranostics ; Intravenous administration ; Iron oxides ; magnetic hyperthermia ; Nanoparticles ; PA imaging ; Precision medicine ; Tumors ; Xenografts ; Xenotransplantation</subject><ispartof>Advanced healthcare materials, 2018-05, Vol.7 (9), p.n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201701201$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201701201$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Zhou, Ping</creatorcontrib><creatorcontrib>Zhao, Heng</creatorcontrib><creatorcontrib>Wang, Quan</creatorcontrib><creatorcontrib>Zhou, Zhiguo</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Deng, Guang</creatorcontrib><creatorcontrib>Wang, Xiyou</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Yang, Hong</creatorcontrib><creatorcontrib>Yang, Shiping</creatorcontrib><title>Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo</title><title>Advanced healthcare materials</title><description>Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the αvβ3‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs.
A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αvβ3‐positive U87MG glioblastoma xenograft model.</description><subject>Fe@Fe3O4 nanoparticles</subject><subject>Fever</subject><subject>Glioblastoma</subject><subject>Hyperthermia</subject><subject>in vivo theranostics</subject><subject>Intravenous administration</subject><subject>Iron oxides</subject><subject>magnetic hyperthermia</subject><subject>Nanoparticles</subject><subject>PA imaging</subject><subject>Precision medicine</subject><subject>Tumors</subject><subject>Xenografts</subject><subject>Xenotransplantation</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kM9Kw0AQxhdRsNRePS94Tt3Z3WySm6X2H7RWsHpdNsnEpqRJ3CRKbz6Cz-iTuKXSOczMN_z4Bj5CboENgTF-b9LtfsgZBAxcvyA9DhH3uPKjy_Mu2TUZNM2OuVI-qBB6xD5vq7YySdU1bZ78fv9MShMXmNIXLDInZ12emjJBmpd0Zd5LPFHzQ4223aLd54ZO8WGKYi3pkymr2liHFNjQrLJ04xB3PHo3dFHSt_yzuiFXmSkaHPzPPnmdTjbjubdczxbj0dLb8SgCD1QUKjRxEEMaAgBHnkjpowmkERhjLGTiZxmGIo39xDcmlbFK0Jc8AMgCJvrk7uRb2-qjw6bVu6qzpXupORNK8CjgylHRifrKCzzo2uZ7Yw8amD7mqo-56nOuevQ4X52V-ANMeHIm</recordid><startdate>20180509</startdate><enddate>20180509</enddate><creator>Zhou, Ping</creator><creator>Zhao, Heng</creator><creator>Wang, Quan</creator><creator>Zhou, Zhiguo</creator><creator>Wang, Jing</creator><creator>Deng, Guang</creator><creator>Wang, Xiyou</creator><creator>Liu, Qian</creator><creator>Yang, Hong</creator><creator>Yang, Shiping</creator><general>Wiley Subscription Services, Inc</general><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20180509</creationdate><title>Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo</title><author>Zhou, Ping ; 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Herein, c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the αvβ3‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs.
A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αvβ3‐positive U87MG glioblastoma xenograft model.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adhm.201701201</doi><tpages>9</tpages></addata></record> |
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| subjects | Fe@Fe3O4 nanoparticles Fever Glioblastoma Hyperthermia in vivo theranostics Intravenous administration Iron oxides magnetic hyperthermia Nanoparticles PA imaging Precision medicine Tumors Xenografts Xenotransplantation |
| title | Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo |
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